7T MRS paper:GABA, Gln/Glu in schizophrenia

Our study entitled

"7T proton magnetic resonance spectroscopy of GABA, glutamate, and glutamine reveals altered concentrations in schizophrenia patients and healthy siblings" 

by Katy ThakkarLara Rösler, Jannie Wijnen, Vincent Boer, Dennis Klomp, Wiepke CahnRené Kahn and Bas Neggers

was just accepted for publication in Biological Psychiatry.


In this study, we used novel high field (7T) MRI methods to measure several metabolic processes in brain areas of schizophrenic patients, their family members and a healthy matched control group. We used new proton magnetic resonance spectroscopy (1H-MRS) techniques to accomplish this. We found that cortical GABA concentration, an inhibitory neurotransmitter, was lowered in Schizophrenia patients only, indicating that this is due to the disease itself or medication effects. We also observed reduced cortical Glutamate concentration, an excitatory neurotransmitter, in both schizophrenia patients as well as their healthy relatives, indicating that this is due to a possibly genetic predisposition to the disease.

These findings together with the experimental design we adopted indicates how neurotransmission systems might be altered in schizophrenia, and disentangle which specific processes give rise to the disease itself and which might be caused by the disease and medication.

Read more about the ongoing project here.
The link to the journa's website with the full paper will be posted here as soon as it appears in Biological Psychiatry.

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