Biography

Bas Neggers was trained as a biophysicist at the University of Nijmegen, the Netherlands, and received his MSc degree in experimental physics in 1996. He obtained his PhD from the Ludwig-Maximilian-University of Munich in 2000 while working at the Max-Planck-Institute in Munich. After returning to the Netherlands in 2001 he worked as a PostDoc at the Helmholtz Institute in Utrecht on visuo-motor control, where he developed several novel functional neuroimaging and transcranial magnetic stimulation (TMS) techniques. After working for 2 years as an assistant professor at Utrecht University, he accepted an assistant professorship at the neuroimaging research group of Prof. Dr. Hulshoff-Pol at the University Medical Center Utrecht. He accepted an associate professorship at the UMC Utrecht early 2013. He currently heads the neuro STimulation and Registration Lab (STARlab) that works on functional neuroimaging and neurostimulation methods, neurocomputational modeling and the control of action preparation in healthy subjects and patients with several disorders. In november 2011, he founded an innovative startup company 'Brain Science Tools BV', where techniques from the STARlab are brought to market.

Research interests

Neural control of action, response selection, fronto-basal control networks, neuropsychiatric disorders, functional MRI, Transcranial Magnetic Stimulation

Current Projects

• Cortico-basal control of action selection (NCU)
• Cortico-cerebellar networks in learning to select
• Measuring striatal lactate as a marker for dopamine (NCU) 
• Devices for NeuroControl and NeuroRehabilitation (DeNeCor: EU)
• Transcranial Magnetic Stimulation during functional MRI

Publications

• Petrov, P.I., Mandija, S., Sommer, I.E., Van den Berg, C., and Neggers, S.F. (2017). How much detail is needed in modeling a transcranial magnetic stimulation coil: measurements and brain simulations. PLoS One. 2017 Jun 22;12(6):e0178952.
   
• Mandija, S., Petrov, P.I., Neggers, S.F.W., Luijten, P.R., and van den Berg, C.A.T. (2016). MR-based measurements and simulations of the magnetic field created by a realistic transcranial magnetic stimulation (TMS) coil and stimulator. NMR Biomed 29, 1590–1600.
   
• Thakkar, K.N., van den Heiligenberg, F.M.Z., Kahn, R.S., and Neggers, S.F.W. (2016). Speed of saccade execution and inhibition associated with fractional anisotropy in distinct fronto-frontal and fronto-striatal white matter pathways. Hum Brain Mapp 37, 2811–2822.
   
• Koops, S., Dellen, E. van, Schutte, M.J.L., Nieuwdorp, W., Neggers, S.F.W., and Sommer, I.E.C. (2016). Theta Burst Transcranial Magnetic Stimulation for Auditory Verbal Hallucinations: Negative Findings From a Double-Blind-Randomized Trial. Schizophr Bull. 42(1):250-7
   
• Mandija, S., van Lier, A.L.H.M.W., Katscher, U., Petrov, P.I., Neggers, S.F.W., Luijten, P.R., and van den Berg, C.A.T. (2016). A geometrical shift results in erroneous appearance of low frequency tissue eddy current induced phase maps. Magn Reson Med. 76(3):905-12. 
   
• Sommer, I.E., and Neggers, S.F.W. (2014). Repetitive transcranial magnetic stimulation as a treatment for auditory hallucinations. Neuropsychopharmacology 39, 239–240.
   
• Neggers, S.F.W., Petrov, P.I., Mandija, S., Sommer, I.E.C., and van den Berg, N.A.T. (2015). Understanding the biophysical effects of transcranial magnetic stimulation on brain tissue: the bridge between brain stimulation and cognition. Prog. Brain Res. 222, 229–259.
   
• A.D. de Weijer AD, I.E. Sommer, E.J. Bakker, M. Bloemendaal, C.J. Bakker CJ, D.W. Klomp, S. Bestmann, S.F.W. Neggers (2014). A setup for administering TMS to medial and lateral cortical areas during whole-brain FMRI recording. J Clin Neurophysiol. 31(5):474-87.
   
• A.D. de Weijer, I.E. Sommer, A. Lotte Meijering, M. Bloemendaal M, S.F.W. Neggers, K Daalman, EH Boezeman (2014). High frequency rTMS; a more effective treatment for auditory verbal hallucinations? Psychiatry Res.224(3):204-10
   
• K.N. Thakkar, F.M. van den Heiligenberg, R.S. Kahn, S.F.W. Neggers (2014) Frontal-subcortical circuits involved in reactive control and monitoring of gaze. J Neurosci. 25;34(26):8918-29.
   
• Jansma JM, van Raalten TR, Boessen R, Neggers SF, Jacobs RH, Kahn RS, Ramsey NF.fMRI guided rTMS evidence for reduced left prefrontal involvement after task practice. PLoS One. 2013 Dec 20;8(12):e80256
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• T.P. Gutteling, S.Y. Park, J.L. Kenemans,  S.F.W. Neggers (2013). TMS of the anterior intraparietal area selectively modulates orientation change detection during action preparation. J Neurophysiol. 110(1):33-41.
   
• K.M. Sharika, S.F.W. Neggers. T.P. Gutteling, S. van der Stigchel, C.H. Dijkerman, A. Murthy (2013). Proactive control of sequential saccades in the human supplementary eye field. Proc Natl Acad Sci U S A. 110(14):E1311-20
   
• S.E. Bosch, S.F.W. Neggers, S. van der Stigchel (2013). The role of the frontal eye fields in oculomotor competition: image-guided TMS enhances contralateral target selection. Cerebral Cortex 23(4):824-32.
   
• B.B. Zandbelt, M. Bloemendaal, S.F.W. Neggers, R.S. Kahn, M. Vink (in press). Expectations and violations: delineating the neural network of proactive inhibitory control. Human Brain Mapping
   
• S.F.W. Neggers, R.M. van Diepen, B.B. Zandbelt, M. Vink, R.C.W. Mandl, T. P. Gutteling (2012). A functional and structural investigation of the human fronto-basal volitional saccade network. PLoS ONE 7(1): e29517. doi:10.1371/journal.pone.0029517
   
• A.D. de Weijer, S.F. Neggers, K.M. Diederen, R.C. Mandl, R.S. Kahn, H.E. Hulshoff Pol, I.E. Sommer (in press). Aberrations in the arcuate fasciculus are associated with auditory verbal hallucinations in psychotic and in non-psychotic individuals. Human Brain Mapping, doi: 10.1002/hbm.21463
   
• M. Panouillères, S.F.W. Neggers, T.P. Gutteling, R. Salemme,S. Van der Stigchel, J.N. Van der Geest, M.A. Frens, D. Pélisson (2011). Transcranial Magnetic Stimulation and Motor plasticity in human lateral cerebellum: dual effect on saccadic adaptation. Human Brain Mapping, doi:10.1002/hbm.21301
   
• A.D. de Weijer, R.C. Mandl, K.M. Diederen, S.F. Neggers, R.S. Kahn, H.E. Pol, I.E. Sommer (2011). Microstructural alterations of the arcuate fasciculus in schizophrenia patients with frequent auditory verbal hallucinations. Schizophr Res 130(1-3):68-77
   
• K.M.J. Diederen, K. Daalman, A.D. de Weijer, S.F.W. Neggers, W. van Gastel, J.D. Blom, R.S. Kahn and I.E.C. Sommer (in press). Auditory hallucinations elicit similar brain activation in psychotic and non-psychotic individuals. Schizophrenia Bulletin
   
• T.P. Gutteling, J.L. Kenemans and S.F.W. Neggers (2011). Grasping Preparation Enhances Orientation Change Detection. Plos One 6(3):e17675
   
• M.E. Struiksma, M.L. Noordzij, S.F. Neggers, W.M. Bosker, A. Postma (2011). Spatial language processing in the blind: evidence for a supramodal representation and cortical reorganization. PLoS One 6(9):e24253
   
• Somers M, Neggers SF, Diederen KM, Boks MP, Kahn RS, Sommer IE (2011). The Measurement of Language Lateralization with Functional Transcranial Doppler and Functional MRI: A Critical Evaluation. Front Hum Neurosci. 5:31.
   
• M. van Elk , H.T. van Schie,S.F.W. Neggers and H. Bekkering (2010). Neural and temporal dynamics underlying visual selection for action. J Neurophysiol.104(2) : 972-983, 2010
   
• A.D. de Weijer, R.C.W. Mandl, I.E. Sommer, M. Vink, R.S. Kahn and S.F.W. Neggers (2010). Human fronto-tectal and fronto-striatal-tectal pathways activate differently during anti-saccades. Front. Hum. Neurosci. 4:41. doi:10.3389/fnhum.2010.00041
   
• K.M. Diederen, S.F.W. Neggers, K. Daalman, J.D. Blom, R. Goekoop, R.S. Kahn, I.E. Sommer (2010). Deactivation of the Parahippocampal Gyrus Preceding Auditory Hallucinations in Schizophrenia. Am J Psychiatry. 167(4):427-35
   
• T.P. Gutteling, H.M. van Ettinger-Veenstra, J.L. Kenemans, S.F.W. Neggers (2010). Lateralized frontal eye field activity precedes occipital activity shortly before saccades: evidence for cortico-cortical feedback as a mechanism underlying covert attention shifts. J Cogn Neurosci. 22(9):1931-43
   
• H.M. van Ettinger-Veenstra, W. Huijbers, T.P. Gutteling, M. Vink, J.L. Kenemans, S.F.W. Neggers (2009). fMRI-guided TMS on cortical eye fields: the frontal but not intraparietal eye fields regulate the coupling between visuospatial attention and eye movements. J Neurophysiol. 102(6):3469-80.
   
• M. van Asselen M, R.P. Kessels, C.J. Frijns, L.J. Kappelle, S.F.W. Neggers, A. Postma (2009). Object-location memory: a lesion-behavior mapping study in stroke patients.Brain Cogn. 71(3):287-94.
   
• B.B. Zandbelt, T.E. Gladwin, M.A. Raemaekers,M. van Buuren, S.F.W. Neggers, R.S. Kahn,N.F. Ramsey, M. Vink (2008). Within-subject variation in BOLD-fMRI signal changes across repeated measurements: quantification and implications for sample size. NeuroImage 42(1):196-206
• S.F.W. Neggers, E.J. Hermans, N.F. Ramsey (2008).  Enhanced sensitivity by fast 3D BOLD fMRI : comparison of SENSE-PRESTO and 2D EPI at 3T. NMR in Biomedicine 21(7):663-76.
   
• I.E. Sommer, K.M. Diederen, J.D. Blom,A. Willems,L. Kushan, K. Slotema,M.P. Boks,K. Daalman,H.W. Hoek, S.F.W. Neggers,R.S. Kahn (2008). Auditory verbal hallucinations predominantly activate the right inferior frontal area. Brain 131(12):3169-77.
   
• Noordzij ML, Neggers SF, Ramsey NF, Postma A. (2008). Neural correlates of locative prepositions. Neuropsychologia, doi:10.1016/j.neuropsychologia.2007.12.022
   
• S.F.W. Neggers, W. Huijbers, C.M. Vrijlandt, B.N.S. Vlaskamp, D.J.L.G. Schutter and J.L. Kenemans (2007). TMS pulses on the frontal eye fields break coupling between visuo-spatial attention and eye movements. Journal of Neurophysiology 98(5):2765-2778
   
• J. Pratt, S.F.W. Neggers (2008). Inhibition of Return in Single and Dual Tasks: Examining Saccadic, Keypress, and Pointing Responses Perception & Psychophysics 70(2):257-65.
   
• I.E. Sommer, K.W. Slotema, A.D. de Weijer,J.D. Blom, K. Daalman, S.F.W. Neggers, M. Somers, W.H. Hoek, A. Aleman, R.S. Kahn (2007). Can fMRI-guidance improve the efficacy of rTMS treatment for auditory verbal hallucinations? Schizofrenia Research 93(1-3):406-8
   
• S.F.W. Neggers, R.H.J. van der Lubbe, N.F. Ramsey, A. Postma (2006). Interactions between ego- and allocentric neuronal representations of space. NeuroImage 15;31(1):320-31
   
• R.H.J. Van der Lubbe, S.F.W. Neggers,R. Verleger, J.L. Kenemans (2006). Spatiotemporal overlap between brain activation related to saccade preparation and attentional orienting. Brain Research 1072(1):133-52.
   
• E. Poljac, S.F.W. Neggers, A.V. van den Berg. (2006) Collision judgment of objects approaching the head. Exp Brain Res., 171(1): 35-46
   
• M. van Asselen M, R.P. Kessels, S.F.W. Neggers, L.J. Kappelle, C.J. Frijns,A. Postma. (2006) Brain areas involved in spatial working memory. Neuropsychologia, 44(7):1185-94.
   
• M. van Asselen M, R.P. Kessels, L.J. Kappelle LJ, S.F.W. Neggers,C.J. Frijns,A. Postma A. (2006)Neural correlates of human wayfinding in stroke patients. Brain Res.5;1067(1):229-38.
   
• S.F.W. Neggers, M.A.H. Raemaekers, E.E.L. Lampmann, A. Postma and N.F. Ramsey (2005). Cortical and subcortical contributions to saccade latency in the human brain Eur J Neurosci, 21(10), 2853-2863.
   
• S.F.W. Neggers, M.L. Scholvinck, R.H. van der Lubbe, A. Postma (2005).Quantifying the interactions between allo- and egocentric representations of space. Acta Psychol, 118(1-2):25-45.
   
• S.F.W. Neggers, R. Langerak, R. Mandl, D. Schutter, P.J.J. Lemmens, A. Postma & N.F. Ramsey(2004). A stereotactic method for image guided transcranial magnetic stimulation validated with fMRI and motor evoked potentials. NeuroImage 21 (4), 1805-1817
   
• S.F.W. Neggers, R. Langerak, R. Mandl, D. Schutter and A. Postma (2003). (f)MRI guided TMS using frameless stereotaxy: validation of NeNa with a cortical map of EMG responses. Neuroimage 19, 67–88. (poster at HBM 2003)
   
• M.L. Noordzij, R.H. van der Lubbe RH, S.F.W. Neggers, A. Postma. (2004). Spatial tapping interferes with the processing of linguistic spatial relations. Can J Exp Psychol. 58(4):259-71
   
• M.H. Fischer, J. Pratt, & S. F.W. Neggers (2003). Inhibition of Return and Manual Pointing Movements. Perception & Psychophysics, 65:379-387
   
• A. Hannus, S.F.W. Neggers, F.W. Cornelissen, H. Bekkering (2003). Selective attention for action: New evidence from visual search studies. In G. Humphreys & J. Riddoch (Eds.) Attention and performance: Attention in action
   
• S.F.W. Neggers and H.Bekkering (2002). Coordinated control of eye and hand movements in dynamic reaching conditions. Human Movement Science, 21,349-376
   
• S. Stork, S.F.W. Neggers and J. Müsseler (2002). Spatial and temporal features of predictive smooth pursuit eye movements.Human Movement Science, 21,335-348.
   
• S.F.W. Neggers and H.Bekkering (2002). Neural Control of Movement Synergy. Guest editorial. Human Movement Science, 21,1
   
• H. Bekkering and S.F.W. Neggers (2002). Visual search is modulated by action intentions. Psychological Science, 13, 370-374
   
• S.F.W. Neggers and H.Bekkering (2001). Gaze anchoring to a pointing target is present during the entire pointing movement and driven by a non-visual signal. Journal of Neurophysiology, 86: 961-970
   
• H. Bekkering, S.F.W. Neggers, R. Walker, B. Gleißner, W.H. Dittrich, C. Kennard (2001). The preparation and execution of saccadic eye and goal-directed hand movements in patients with Parkinson's disease. Neuropsychologia, 39: 173-183
   
• S.F.W. Neggers and H. Bekkering (2000). Ocular Gaze is Anchored to the Target of an Ongoing Pointing Movement.Journal of Neurophysiology 83: 639-651
   
• S. F. W. Neggers, H. Bekkering (1999). Integration of visual and somatosensory target information in goal-directed eye and arm movements.Exp Brain Res 125-1, 97-107
   
• C.C.A.M. Gielen, E. J. Vrijenhoek, T. Flash, and S.F.W. Neggers (1997). Arm Position Constraints During Pointing and Reaching in 3-D Space.Journal of Neurophysiology 78: 660-673