Using fMRI-guided TMS with the NeuralNavigator (TM), we could influence how sequences of eye movements are planned ahead by our brain. Normally the brain areas around the supplementary motor area (SMA) carefully take into account current context and past events in planning our actions. We could disrupt AND restore this ability by stimulating a small brain region in between our cortical hemispheres near SMA: the supplementary eye fields (SEF). The region was first detected with fMRI for all participants and then carefully targeted with image guided TMS, while subjects performed a smartly designed double step saccade task that could suddenly change targets during execution, requiring a fast replanning of a movement while it unfolded.The temporal and spatial characteristics of this fast rescheduling of our eye movements where affected by TMS during current and past trials in a fascinating manner.
Read more in Sharika's paper that appeared in PNAS today: